A Major Cancer Breakthrough That No One Has Heard Of

A cure for early metastatic cancer and HIV that almost nobody knows about? Can it be true?

On November 19, 2008 something touched my life and changed it forever. I had just completed my second book, Outsmarting The Number One Killer (about how to prevent and reverse atherosclerotically-driven heart attacks and strokes) when I came across three seminal studies published earlier that year by internationally recognized research immunologist and molecular biologist, Nobuto Yamamoto, Ph.D. These pivotal papers—which I believe will change the course of medical history—blew me away: Yamamoto had apparently discovered a way to “outsmart” cancer, and was using the body’s own natural healing systems to do it.

“Holy cow!!!” I said to myself. “This guy has discovered a cure for early metastatic cancer. It appears to work 100% of the time!!! No one has ever done that before.”

And this was no “black box” model or statistical study (you know, the kind that make observations but don’t address underlying causal mechanisms. Medicine A cures disease B, but nothing about how it actually works). All the basic science, all the necessary molecular biological information—an impressive display of published research studies from a quarter century of work—was right there for all to see. No smoke and mirrors. Anyone who has studied Dr. Yamamoto’s research papers would have to agree he published an impressively extensive series of serious science masterpieces.

As I learned more I became committed to bringing this powerful new set of ideas into public awareness. It became clear to me that we need to find a way to make GcMAF available to all cancer, HIV, and chronic virus patients, and we need to institute routine annual Nagalase testing to find cancers much earlier than imaging now allows.

If all new cancers were detected early by regular Nagalase testing, we could reverse them with GcMAF—long before X-rays could find them—and put cancer out of business once and for all. This may seem like a rash statement, but I believe it is supported by the facts.

Yamamoto’s three studies showed that incredibly small weekly doses (100 billionths of a gram—an amount that is invisible to the naked eye) of GcMAF had cured early metastatic breast, prostate, and colon cancers in 100% of (nonanemic) patients. In a fourth paper, he used the same treatment to cure 100% of nonanemic HIV-infected patients.

All of Yamamoto’s cancer patients had recently flunked the standard mainstream triad of surgery, chemo, and radiation. They had early metastatic disease, which means that despite the best efforts of conventional medicine, their cancers were out of control and still growing. Their prognoses were poor at best.

Curing metastatic cancer at all is rare. Until Professor Yamamoto discovered and administered GcMAF, no one had ever cured every single case. These are the patients oncologists give up on, the ones that get “palliative” care. Perhaps another round or two of chemo or radiation in the slim hopes of a long-term reversal or a little extra (probably not very high quality) time—but, with metastatic disease, there is no serious expectation of an actual cure. The numbers are profoundly dismal.

Granted, all of Yamamoto’s patients were in the earliest phase of metastatic disease and received GcMAF shortly after the Big Three had failed. For these patients (though a sprinkling might have been saved by additional radiation and/or chemo), the assumption is that their cancers would grow and eventually kill them. GcMAF, remarkably, saved every single one. This is an exceptional outcome and deserves greater scrutiny than it has received.

A fourth study, published in January of 2009, showed Yamamoto—using the same treatment protocol—had removed all signs of viral activity in 100% of HIV infected patients. All patients were free of HIV within 18 weeks. (One must wonder why the AIDS community hasn’t picked up the ball here and run with it?)

Remarkably, Yamamoto accomplished these cures relatively rapidly. The breast and prostate cancer patients were all cured in less than 6 months of weekly GcMAF injections. The colorectal cancer study took about a year to cure all subjects. Five to seven years of careful followup revealed no recurrences in any of the patients. Anyone who is familiar with cancer research would have to find this remarkable.

This was not a “one off,” a “lucky strike.” Yamamoto’s four papers were the culmination of decades of trailblazing research in which he had already proven—via basic science and animal studies—exactly how GcMAF and Nagalase work. The 2008 human trials were just the frosting on a phenomenal cake that took a quarter century to bake. The breadth and depth of the underlying research is important here because misinformed critics suggest that GcMAF is “unproved.” It seems doubtful these naysayers have read the dozens of Yamamoto papers published in peer-reviewed journals between 1979 and 2008 that lay down an unimpeachable foundation for his final proof.

My search for answers

When I first read Yamamoto’s studies, I couldn’t believe it either. A cure for early stage metastatic cancer that’s effective in every single case? Absurd. Published in peer-reviewed journals? No way. I figured there must be some hitch, a mistake, a logical error, a weak link, a fatal flaw—and I was determined to find it—but the deeper I delved, the more convinced I became that GcMAF was for real!

Then I started wondering why I seemed to be among the very few who “got it.”

At first, I spent a huge amount of time enhancing my understanding of the relevant molecular biology, genetics, and immunology. I learned a lot more than I anticipated about cancer, macrophages, oxidative bursts, adhesion molecules, antibodies, phagocytosis, protein chemistry, cytokines, messenger molecules, receptors, N-acetyl-galactosaminidase (Nagalase), and GcMAF. At times I felt as if I had stuffed so much new information into my head that it was going to explode. I needed to understand exactly how it all worked, how all the pieces fit together. I poured over research articles and molecular genetics texts until I felt I had a reasonable grasp of what Yamamoto was doing and saying. I developed the ability to visualize—in great detail—the workings of macrophages battling cancer cells and viruses in this brutal microscopic war.

The more I learned, the more it sunk in: using impeccable science, Yamamoto had found a powerful means of enhancing our bodies’ own anti-cancer, anti-viral weaponry! That’s what cured the cancers.

The more I learned the more I asked the question: why had the medical community—much less the average person—never heard of GcMAF? No article in the print media. No video, no book, no research articles other than Yamamoto’s. No serious scientific web discussions (which is truly extraordinary, because everything is on the internet). Nothing.

Next I turned to what I call “human browsers.” I called a bunch of my physician buddies and molecular biology colleagues—good scientists all—but there, too, I drew a blank every single time. Not a single one of them had ever heard of GcMAF.

Not easily dissuaded, I contacted several immunology researchers at major institutions, and again no one had heard of GcMAF. Maybe someone in the government or research establishments, the FDA (Food and Drug Administration), the NCI (National Cancer Institute), the NIH (National Institutes of Health), American Cancer Society (ACS) knew something? Nope. No one there had ever heard of it either. (Or if they had, they sure weren’t talking.)

In those early months, my level of frustration gradually escalated. Proof of a natural cure for advanced (metastatic) cancer (not to mention HIV and other chronic viral infections) and nobody seemed interested? I just couldn’t understand it.

Finally, a sense of surrealism set in. I had spent hundreds of hours on this, with literally nothing to show for it. Nobody knew anything. And when I tried to explain Yamamoto’s work to some of the people I called, I could hear their eyes were glazing over. I could hear them thinking, “C’mon now, doc. A cure for all cancers? Oh, sure. One that works 100% of the time? On metastatic cancer? Give me a break. It sounds like smoke and mirrors to me.” I started questioning my grasp on reality. No Oprah? No Larry King? No New York Times article? No article anywhere? No media coverage of any kind! No scientific recognition? What the heck is going on here?

Spreading the word about GcMAF

After writing an entire book on the subject, I can still honestly say I don’t know why the average person—not to mention the average physician or the average molecular biologist—has never heard of GcMAF. I hope that sharing this information will create the critical mass we need to overcome the obstacles. So: Hello out there! Here’s a cure for cancer and AIDS!!! It does have its limitations: the cancers must be early metastatiic—but that’s better than anything we have right now.

Even more significantly, here’s a way to rid the planet of the scourge of cancer. I am passing on what I have learned about it to enable you to chip in and work with me to transform GcMAF from a set of abstract concepts to a lifesaving reality. Millions upon millions of lives would be saved if we could make GcMAF—a harmless protein—available to the masses of cancer and HIV patients who desperately need it. And countless cancers would be prevented using Nagalase screening and GcMAF therapy on all adult human populations.

Please help! This is a two-way street. I’ve chosen a reader-editable format (actually, truth be known, my web genius friend and cyberguru, Peter Rowell created it specifically for this book) whereby anyone who is interested can contribute their ideas. The beauty of this approach is that it facilitates collective development of ideas by an organized community. Just scroll over the left vertical green bar, click to open a dialogue box, and share your ideas, edits, corrections, and questions. In doing so, you will have participated in a process that has the potential to help a lot of your fellow humans and to alleviate a huge amount of suffering.

And—as if that weren’t enough of a reward— you’ll also (if you so desire) be listed in the Acknowledgments.

Why GcMAF remains obscure

Here are a few key facts that provide a partial answer to the fascinating question: Why has GcMAF gone unnoticed?

  • Understanding Yamamoto’s work requires a firm grasp of some pretty advanced molecular biology, which most people—even most doctors and researchers—don’t possess. It’s kind of a language problem: if someone shouts “Cancer Cure!!! Cancer Cure!!! Cancer Cure!!!” in Swahili, it is quite possible that the earthshatteringness of it all won’t get through, and everyone will go on about their business as if nothing happened. (In this book I have translated these ideas into everyday language. It’s not that complicated.)
  • To a stodgy medical community that’s resistant to change, GcMAF is just another “unproved therapy.” And an “alternative” one at that. Unproved therapies are not to be trusted. (Even if they’re harmless and bioidentical.)
  • “Proving” this discovery the conventional way would involve developing and promoting a lucrative drug. Doing that takes about a decade and costs over 100 million dollars. Beyond time and money, it requires a lot of biochemical know-how and some sophisticated equipment. Brewing it up in your basement lab with a chemistry set and a bunch of buddies is not an option. Big Pharma isn’t interested because there’s no cash cow at the end of this rainbow. GcMAF—like all chemicals our body is programmed to make—can’t be patented because it fits the FDA’s definition of “natural” (translation: “unpatentable”).
  • Even if they could profit from GcMAF, the pharmaceutical arm of the cancer industry wouldn’t be interested because they don’t really want cancer to go away. This may seem harsh, but it’s true. Many incomes would be interrupted if cancer and HIV suddenly ceased to exist. Government agencies would have to be closed, oncologists would have to be retrained, researchers redirected, cancer treatment centers shut down or converted to screening and prevention facilities—and that’s just the tip of the iceberg. We’re talking profound social upheaval here. Cancer is entrenched and institutionalized, and vanquishing it would cause major fireworks. These fears are largely unfounded, however. For optimum effectiveness, GcMAF and Nagalase testing will need to be integrated into the existing cancer care system, so we need the system.
  • To understand GcMAF and Nagalase we must embrace an entirely new model—a completely different approach to cancer and chronic viral infections. There is no super drug, no magic bullet. Our bodies already know how to cure cancer and viral infections; we simply need to enhance these systems using natural medicines. That’s how GcMAF works.
  • The old “wait until cancer has gotten so big that we can see it on imaging, and then slash and burn it out” approach has really got to go. If we are going to commit to stopping these epidemics, our new direction must be annual screening (with Nagalase or AMAS testing) for early detection, then nipping cancer in the bud with GcMAF.



What is Nagalase?

Nagalase is a protein made by all cancer cells and viruses (HIV, hepatitis B, hepatitis C, influenza, herpes, Epstein-Barr virus, and others). Its formal, official chemical name is alpha-N-acetylgalactosaminidase, but this is such a tongue-twisting mouthful of a moniker that we usually just call it “Nagalase.” (Sometimes, when I want to impress friends with my brilliance, I’ll say the entire word real fast: “alpha-N-acetylgalactosaminidase.” I have found that it’s important to practice beforehand if one doesn’t want to embarrass oneself.)

Why is Nagalase important?

  1. Nagalase causes immunodeficiency. Nagalase blocks production of GcMAF, thus preventing the immune system from doing its job. Without an active immune system, cancer and viral infections can grow unchecked.
  2. As an extremely sensitive marker for all cancers, Nagalase provides a powerful system for early detection.
  3. Serial Nagalase testing provides a reliable and accurate method for tracking the results of any therapeutic regimen for cancer, AIDS, or other chronic viral infection.

Nagalase proves that cancer cells break all the rules

Normal healthy cells cooperate with one another in a concerted effort to further the good of all. Cancer cells refuse to play ball. Their disdainful attitude toward the rest of our cellular community is appalling. For example, these cellular scofflaws ignore clear messages to stop growing and spreading and encroaching on their neighbor’s space. How would you like it if your neighbor moved his fence over into your backyard?

Of all the rules cancer cells break, none is more alarming than the production of Nagalase, the evil enzyme that completely hog-ties the immune system army’s ability to stop cancer cells.

Virus particles also make Nagalase. Their goal is the same as that of the cancer cells: survival by incapacitating their number one enemy: the immune system.

Nagalase precision

Like a stealth bomber, the Nagalase enzyme synthesized in and released from a cancer cell or a virus particle pinpoints the GcMAF production facilities on the surface of your T and B lymphocytes and then wipes them out with an incredibly precise bomb. How precise? Let me put it this way: Nagalase locates and attacks one specific two-electron bond located at, and only at, the 420th amino acid position on a huge protein molecule (DBP), one of tens of thousands of proteins, each containing millions of electrons. This is like selectively taking out a park bench in a major city from six thousand miles away. More astonishing, if that is possible, Nagalase never misses its target. There is no collateral damage.

As you already know, GcMAF is a cell-signaling glycoprotein that talks to macrophages, enabling them to rapidly find, attack, and kill viruses and cancer cells. By activating macrophages, GcMAF triggers a cascade that activates the entire immune system. Blockage of GcMAF production by Nagalase brings all this wonderful anti-cancer and anti-viral immune activity to a screeching halt, allowing cancer and infections to spread.

What does Nagalase actually do? How does it destroy immune functioning and deactivate macrophages?

Once synthesized and released into nearby tissue or into the bloodstream, Nagalase, like that drill sergeant at boot camp, shouts harsh commands at the vitamin D binding protein (DBP) that is about to be turned into GcMAF. Nagalase demands that DBP not, under any circumstances, attach itself to a specific sugar molecule (galactosamine). If DBP has already grabbed (i.e., connected to, using a two-electron, “covalent” bond) a galactosamine sugar molecule, it is commanded to immediately let go. “Leave galactosamine alone, or you’ll be in big trouble!!!” is the Nagalase sergeant’s command. We’ll probably never know whether or not, on some deeper level, DBP knows that Nagalase’s motives are dastardly—but it doesn’t really matter: DBP will definitely always obey. Like the army private, the DBP literally has no choice. Because of the way hierarchies work in cellular biology, proteins must do the bidding of their enzymes. The enzymes, like Nagalase, are the drill sergeant and the proteins, like DBP, are the privates. That’s just the way it is. Obeying the drill sergeant’s command means DBP can’t do its assigned task, that of becoming GcMAF. It is rendered useless. For DBP, on a molecular level, life no longer has meaning.

Unfortunately for cancer and viral patients, DBP had been on its way to becoming GcMAF until the Nagalase drill sergeant so rudely interrupted. Now GcMAF—the one protein our bodies need in order to activate our immune systems—can’t be made. Immune activity screeches to a halt. The defense system protecting us from cancers and viruses has been snuffed out.

Nagalase, using this astonishingly simple yet cunningly subversive technique, emasculates the GcMAF precursor protein (DBP) by knocking off its three sugar molecules. One quick whack by Nagalase and the DBP protein that would have become a GcMAF molecule now limps off into the sunset, permanently disfigured and disabled. With one simple, swift maneuver, Nagalase has brought the entire immune system to its knees.

Here’s how Dr. Yamamoto put it (for clarity, I’ve replaced some of the technical words):

“Serum vitamin D3-binding protein (DBP) is the precursor for the principal macrophage activating factor (GcMAF). The precursor activity of serum DBP was reduced… These patient sera contained alpha-N-acetylgalactosaminidase (Nagalase) that deglycosylates (removes the sugars from) DBP. Deglycosylated DBP cannot be converted to GcMAF, thus it loses the GcMAF precursor activity, leading to immunosuppression.” (Microbes Infect. 2005 Apr;7(4):674-81. Epub 2005 Mar 22. Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the hemagglutinin of influenza virus. Yamamoto N, Urade M.)

Nagalase testing: former mass murderer now works for the good guys

It’s easy to be a little schizy about Nagalase. On the one hand, this nasty protein’s behavior toward us has been reprehensible and disastrous. Working in cahoots with cancer and HIV—not shy about getting into bed with our mortal enemies—Nagalase can rightfully claim direct responsibility for billions of human deaths. And it would just as soon add you to the list, so we don’t have to be shy about placing Nagalase in the “genocidal murderer” column.

With the advent of Nagalase testing, however, this bad actor now will be harnessed to a useful purpose. By providing us with precise and reliable advance information about enemy operations, Nagalase blood level testing becomes a “Deep Throat” double agent for cancer. He helps us by giving us an early warning sign.

Early detection (using AMAS or Nagalase) saves lives

You don’t want a cancer to have gotten out of control by the time you find and start treating it. When cancers are still young and small, gentle natural therapies are the most effective. Alternative treatments work best on early small cancers by enhancing immune functioning and removing the source of the inflammation that is causing the cancer in the first place. Cancers that have become large enough to see on imaging pose a much more significant threat, and the big guns now become necessary.

The current method for diagnosing most cancers requires us to wait until a mass shows up on imaging (e.g., a mammogram, chest X-ray, or colonoscopy). This approach wastes valuable time and causes needless deaths. But long before imaging can find it, a positive Nagalase (or AMAS test) can tell us that early stage cancer exists somewhere in the body. By enabling earlier and therefore less invasive treatment options, this information provides a huge head-start.

Normally present at only trace levels, Nagalase shows up in the blood when a cancer or virus appears

The malignant and viral entities that make Nagalase are not normally present, so its appearance is a big deal from a diagnostic perspective. When Nagalase shows up, even in very small amounts, we have the earliest glimpse of a new cancer or viral infection. The old adage, “Where there’s smoke, there’s fire” applies here. A positive Nagalase test notifies us that a cancer (or a nasty virus) lurks within.

Nagalase appears in the blood stream when a nascent cancer is just a minute cluster of abnormal cells, long before conventional diagnostic methods can detect it. Through blood testing, we can find this red flag, even when present at exceedingly low levels. Providing us with this early warning sign might not quite qualify Nagalase for the “Good Samaritan” award, but I could go with “extremely useful.” Like a rehabilitated criminal on parole, the potential for harm is still there. For now, however, he’s staying out of trouble and doing community service. Turn your back and he’s a mass murderer again.

Using Nagalase testing to track cancer treatment

Rising Nagalase levels indicate a cancer or virus is growing and spreading. Conversely, Nagalase levels will decrease if the cancer or infection is being effectively destroyed.

Any treatment that lowers cancer cell (or viral numbers) will lower Nagalase levels. Nagalase will, for example, always drop after surgery (whether or not the entire tumor was removed). Chemotherapy and radiation also reduce Nagalase levels. So does GcMAF. If, after these treatments, the depressed level begins to rise again, this is the warning sign that the cancer was not completely removed, and/or that metastatic disease is hiding out somewhere. With viral infections, increasing Nagalase levels indicate return of the infection.

Consecutive rising Nagalase levels are therefore a red flag, warning us it may be time to entertain new treatment options. Conversely, if levels are going down, stay the course: the cancer or virus is going away.

Flat-earth medicine

Many medical professionals don’t feel comfortable with “nonspecific” tests like Nagalase. It drives them nuts to discover that a cancer is lurking somewhere inside without knowing exactly where it is located. “How,” they ask, “do you expect me to treat a cancer I can’t see? Why, I’m not going to tilt at windmills!” This may be a signal that you need to find a different doctor, perhaps one who works in an alternative cancer clinic. Here you will find highly-trained professionals who understand the concept that cancer is a molecular biological change long before it presents visually (by this I mean becomes viewable on imaging).

When GcMAF becomes available, the answer will be easier: a six month course of weekly 100 ng GcMAF intramuscular injections with monthly Nagalase level tests to follow the Nagalase level as it goes back down to baseline. The cancer can be declared cured, even though it never reached life-threatening proportions. (We have a long way to go before this kind of medical behavior will be commonplace and acceptable. The sooner the better, however.)

Nagalase role “under-appreciated”

Nagalase, arguably our most immunosuppressive protein molecule, poses an enormous threat in terms of cancer perpetuation and viruses’ ability to continually defeat us. Yet cancer researchers have not shown any interest in it. (Maybe I’m being a little too generous here; perhaps “clueless” would be more a more accurate depiction.) Why don’t they get it that blasting cancer cells into oblivion with chemo and radiation is usually not sufficient to stop advanced disease and does nothing to address the cause: immunosuppression. Even if we ignore for the moment the excessive collateral damage caused by chemo drugs and radiation, the patient also needs—requires—a healthy immune system to finish the job. If we don’t revive immune function by disabling Nagalase, the cancers and viruses will just keep roaring back. Restoring immunocompetence by negating the stultifying effect of Nagalase should therefore become a primary research goal.

Source: Tim Smith MD


Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s